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L-5-MTHF, 60 Caps

Designs For Health

  • $ 18.50

L-5-MTHF is the activated form of folate, necessary for patients who have an MTHFR mutation such that they cannot adequately activate folate from food. 

Caution: If you have more than one MTHFR mutation, you may not be able to handle this high a dose all at once. Detox reactions can occur (because certain enzymatic "machinery" that didn't work well before is suddenly overloaded). If you experience this: 

  • Stop the MTHF for 1-2 weeks, until you feel better 
  • Add in some extended release niacin (50-100 mg daily - you may have to cut them because they tend to come in 250 mg per cap). Niacin binds methyl groups and also increases the breakdown of glutamate (excitatory). 
  • Add some vitamin B6 (50-100 mg, which will convert glutamate to GABA). 
  • Add in hydroxycobalamin (1000 mcg). 
  • Anti-inflammatory herbs like curcumin to quench some of the excess inflammation. 
  • Minimize your leafy greens until things die down bc those contain methylfolate and nitrates. 
  • Make sure electrolyte packets daily (or electrolyte water) since methylfolate increases cell division and can lead to electrolyte deficiencies (and you were already set up for those).
  • Once symptoms calm down, go back on the 5MTHF again.

Recommended Dose: 1 cap daily if well tolerated.


Serving Size: 2 capsules

Amount Per Serving:
... 1000mcg
(as [6S]-5-Methyltetrahydrofolate)

Other Ingredients: Microcrystalline cellulose, spinach juice powder, L-leucine.

Does not contain Gluten.

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